Coming Together for Major Depressive Disorder

Help Advance Research for Major Depressive Disorder

Join a Clinical Research Study for Adults with Depression in New York

If you live in or near the New York area, are between 18 and 85 years old, and have been diagnosed with major depressive disorder (MDD), you may be able to participate in a clinical research study.

This study is for adults who are currently taking a single antidepressant medication but feel their symptoms have not improved enough. Researchers are studying whether an investigational medication, together with structured psychological support, may help reduce symptoms of depression compared with placebo (a treatment with no active ingredients).

There is no cost to participate. All study-related care is provided as part of the research. Compensation may be available.

Participation is voluntary, and you may choose to stop at any time.

This is a research study and is not intended to replace your current medical care.

Why Participate?

Help Advance Depression Research
By taking part, you can contribute to clinical research focused on developing new treatment options for people living with major depressive disorder.

Additional Monitoring and Support
Participants receive regular clinical monitoring, structured psychological support sessions, and ongoing check-ins with the study team throughout the study 

No Cost to Participate
All study-related visits and procedures are provided at no cost. Participants may also be reimbursed for study-related time and reasonable travel expenses.

What’s Involved?

If eligible and choose to participate, you may be asked to:

• • Continue taking your current antidepressant medication at a stable dose, as confirmed by the study doctor
  • Be randomly assigned to receive two oral doses of either the investigational study medication or placebo
  • Take part in structured psychological support sessions
  • Attend a combination of in-person and remote study visits
  • Be part of a double-blind study, meaning neither you nor the study staff will know whether you receive the investigational medication or placebo

Who May Be Eligible?

• Are 18–85 years old
• Have been diagnosed with major depressive disorder
• Experienced your first episode of depression before age 60
• Are currently taking an antidepressant that has provided less than 50% symptom improvement
• Are willing to commit to study visits and procedures

• Have certain psychiatric conditions such as schizophrenia or bipolar disorder
• Have a recent history of substance use disorder
• Have used psychedelic substances within the past year, or more than 10 times in your life
• Have used ketamine or esketamine within the past 6 months
• Have certain medical conditions that could interfere with study participation
• Are unable or unwilling to comply with study requirements
• Final eligibility will be determined by the study team after additional screening

Ready to Learn More?

If you are interested, please complete the intake form on this page. A member of the study team will review your information and contact you to discuss next steps.

Submitting the form does not obligate you to participate—it’s simply the first step in learning more.

A member of the study team will be available to answer your questions and support you throughout the screening process.

Study Site Locations:

Adams Clinical Harlem
345 E. 102nd Street New York NY 10029

Davis Clinical (Adams Clinical Bronx)
1200 Waters Place Bronx NY 104619

Questions?

Additional information about this study may be available through participating locations listed below.

For New York Residents:

Neergaard Pharmacy 120 7th Avenue, Brooklyn, NY 11215

Rye Beach Pharmacy 464 Forest Ave, Rye, NY 10580